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R. Daniel Bonfil, Ph.D.

R. Daniel Bonfil
(954) 262-4342


  • University of Buenos Aires, Argentina


Cancer Biology


Dr. R. Daniel Bonfil obtained his Licentiate (equivalent to combined B.Sc. and M.Sc. in the US) and Ph.D. degrees from the University of Buenos Aires, Argentina, and completed his post-doctoral training at the Fox Chase Cancer Center, Philadelphia, PA. He served as Tenured Research Investigator at the National Council for Scientific and Technological Research (CONICET), directing research groups at the National Academy of Medicine and later at the Center for Pharmacological Studies (CEFYBO), both in Buenos Aires, Argentina. His research focused on the mechanisms driving cancer invasion and metastasis, and the phenomenon of “concomitant antitumor resistance”, by which the growth of distant secondary tumor implants or metastases in tumor-bearing hosts is often inhibited by the presence of a primary tumor. His work was the foundation for later discoveries of anti-angiogenic factors, which today are part of the arsenal in cancer treatment, such as Avastin. He also was Scientific Director of the non-for profit organization FUNDIC (Cancer Research Foundation, Buenos Aires), where he was committed for almost one decade to both cancer research and the promotion of cancer awareness through education and community outreach to children and underserved population. In 2002, Dr. Bonfil joined Wayne State University School of Medicine (WSU-SOM), Detroit, MI, where he was Associate Professor at the Departments of Urology and Pathology, and had a secondary appointment at the Department of Oncology as scientific member of the Karmanos Cancer Institute. During his 15-year term at WSU-SOM, Dr. Bonfil’s research led to significant observations on the molecular and cellular mechanisms that drive bone metastasis, a major clinical complication in men with metastatic castrate-resistant prostate cancer. Much of his scientific activity was funded by intramural and extramural (National Institutes of Health, and Department of Defense) grants, and has centered on the investigation of the cross-talk between cancer cells and the tumor microenvironment, resulting in novel findings on the role of matrix metalloproteinases, and receptor tyrosine kinases, such as c-kit and discoidin domain receptors (DDRs), in bone metastasis. He directed many Ph.D. theses, mentored numerous trainees, including postdoctoral, masters, and undergraduate students, and taught graduate courses in the Cancer Biology Graduate Program, Pathology, and Interdisciplinary Biomedical Science. Dr. Bonfil is Editorial Board member of three medical journals, Editor of the Section Oncologic Pathology of Current Oncology, and reviewer for numerous health sciences journals. His scientific work is well documented by peer-reviewed publications and chapters in books that add up to around 100, and by more than 90 abstracts presented at national and international scientific meetings. In 2017, he joined Nova Southeastern University, where he serves as Professor of the Department of Pathology at the College of Medical Sciences actively teaching Medical, Dental, Pharmacy, and Optometry students.

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